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The Nucleoside Uridine Isolated in the Gas Phase
Author(s) -
Peña Isabel,
Cabezas Carlos,
Alonso José L.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412460
Subject(s) - uridine , nucleoside , uracil , intramolecular force , chemistry , hydrogen bond , ribose , gas phase , stereochemistry , photochemistry , rna , molecule , dna , organic chemistry , biochemistry , enzyme , gene
Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′‐ endo ‐g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.