Copper(I)‐Catalyzed Alkylation of Polyfluoroarenes through Direct CH Bond Functionalization | Zendy

Xu Shuai | Zendy; Wu Guojiao | Zendy; Ye Fei | Zendy; Wang Xi | Zendy; Li Huan | Zendy; Zhao Xia | Zendy; Zhang Yan | Zendy; Wang Jianbo | Zendy

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Copper(I)‐Catalyzed Alkylation of Polyfluoroarenes through Direct CH Bond Functionalization

Author(s) -

Xu Shuai,

Wu Guojiao,

Ye Fei,

Wang Xi,

Li Huan,

Zhao Xia,

Zhang Yan,

Wang Jianbo

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201412450

Subject(s) - alkylation , surface modification , carbene , chemistry , diazo , copper , catalysis , combinatorial chemistry , fluorine , organic chemistry , polymer chemistry

The copper(I)‐catalyzed alkylation of electron‐deficient polyfluoroarenes with N‐tosylhydrazones and diazo compounds has been developed. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of C(sp 2 )C(sp 3 ) bonds with polyfluoroarenes through direct CH bond functionalization. Mechanistically, copper(I) carbene formation and subsequent migratory insertion are proposed as the key steps in the reaction pathway.

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