Enantioselective Intramolecular Hydroacylation of Unactivated Alkenes: An NHC‐Catalyzed Robust and Versatile Formation of Cyclic Chiral Ketones | Zendy

JanssenMüller Daniel | Zendy; Schedler Michael | Zendy; Fleige Mirco | Zendy; Daniliuc Constantin G. | Zendy; Glorius Frank | Zendy

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Enantioselective Intramolecular Hydroacylation of Unactivated Alkenes: An NHC‐Catalyzed Robust and Versatile Formation of Cyclic Chiral Ketones

Author(s) -

JanssenMüller Daniel,

Schedler Michael,

Fleige Mirco,

Daniliuc Constantin G.,

Glorius Frank

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201412302

Subject(s) - hydroacylation , enantioselective synthesis , intramolecular force , carbene , catalysis , chemistry , olefin fiber , organic chemistry , aldehyde

A highly enantioselective intramolecular N‐heterocyclic carbene (NHC)‐catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin‐substituted aldehydes (up to 99 % ee ). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC‐catalyzed hydroacylation reaction for the first time.

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