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Enantioselective Intramolecular Hydroacylation of Unactivated Alkenes: An NHC‐Catalyzed Robust and Versatile Formation of Cyclic Chiral Ketones
Author(s) -
JanssenMüller Daniel,
Schedler Michael,
Fleige Mirco,
Daniliuc Constantin G.,
Glorius Frank
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412302
Subject(s) - hydroacylation , enantioselective synthesis , intramolecular force , carbene , catalysis , chemistry , olefin fiber , organic chemistry , aldehyde
A highly enantioselective intramolecular N‐heterocyclic carbene (NHC)‐catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin‐substituted aldehydes (up to 99 % ee ). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC‐catalyzed hydroacylation reaction for the first time.