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Caterpillar Track Complexes in Template‐Directed Synthesis and Correlated Molecular Motion
Author(s) -
Liu Shiqi,
Kondratuk Dmitry V.,
Rousseaux Sophie A. L.,
GilRamírez Guzmán,
O'Sullivan Melanie C.,
Cremers Jonathan,
Claridge Tim D. W.,
Anderson Harry L.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412293
Subject(s) - nanoring , random hexamer , histone octamer , template , chemistry , conrotatory and disrotatory , dimer , porphyrin , stereochemistry , trimer , crystallography , materials science , ring (chemistry) , photochemistry , nanotechnology , organic chemistry , dna , biochemistry , nucleosome , histone
Small alterations to the structure of a star‐shaped template totally change its mode of operation. The hexapyridyl template directs the conversion of a porphyrin dimer to the cyclic hexamer, but deleting one pyridine site changes the product to the cyclic decamer, while deleting two binding sites changes the product to the cyclic octamer. This surprising switch in selectivity is explained by the formation of 2:1 caterpillar track complexes, in which two template wheels bind inside the nanoring. Caterpillar track complexes can also be prepared by binding the hexapyridyl template inside the 8‐ and 10‐porphyrin nanorings. NMR exchange spectroscopy (EXSY) experiments show that these complexes exhibit correlated motion, in which the conrotatory rotation of the two template wheels is coupled to rotation of the nanoring track. In the case of the 10‐porphyrin system, the correlated motion can be locked by binding palladium(II) dichloride between the two templates.