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Ruthenium‐Catalyzed Synthesis of 2,3‐Cyclo[3]dendralenes and Complex Polycycles from Propargyl Alcohols
Author(s) -
Thies Nora,
Haak Edgar
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412207
Subject(s) - ruthenium , propargyl , catalysis , combinatorial chemistry , cascade , natural product , chemistry , diene , organic chemistry , natural rubber , chromatography
Ruthenium‐catalyzed cascade transformations for the synthesis of 2,3‐cyclo[3]dendralenes and multicomponent processes based thereon to generate complex polycycles are presented. The combination of allylation–cyclization sequences with diene‐transmissive Diels–Alder reactions allows the rapid and selective construction of natural‐product‐like motifs from easily accessible starting materials in a one‐pot process and provides a new method to access potential drug candidates.