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Photoswitching the Cytotoxic Properties of Platinum(II) Compounds
Author(s) -
Presa Andreu,
Brissos Rosa F.,
Caballero Ana Belén,
Borilovic Ivana,
KorrodiGregório Luís,
PérezTomás Ricardo,
Roubeau Olivier,
Gamez Patrick
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412157
Subject(s) - platinum , cytotoxic t cell , chemistry , combinatorial chemistry , ligand (biochemistry) , metal , pact , stereochemistry , nanotechnology , materials science , biochemistry , catalysis , organic chemistry , receptor , in vitro , archaeology , history
The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of “photomodifying” a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2‐dithienylethene‐containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA‐interacting properties and cytotoxic behaviors.