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Nickel‐Catalyzed Monofluoromethylation of Aryl Boronic Acids
Author(s) -
Su YiMing,
Feng GuangShou,
Wang ZhenYu,
Lan Quan,
Wang XiSheng
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412026
Subject(s) - aryl , catalysis , nickel , catalytic cycle , chemistry , combinatorial chemistry , derivative (finance) , ezetimibe , boronic acid , organic chemistry , statin , biochemistry , business , alkyl , finance
Aryl boronic acids can be monofluoromethylated under nickel catalysis. The utility of this method is demonstrated by the monofluoromethylation of a borylated and acyl‐protected derivative of the statin drug ezetimibe. Mechanistic investigations indicate that a fluoromethyl radical is involved in the Ni I /Ni III catalytic cycle.
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