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Heterogeneously Catalyzed Direct CH Thiolation of Heteroarenes
Author(s) -
VásquezCéspedes Suhelen,
Ferry Angélique,
Candish Lisa,
Glorius Frank
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411997
Subject(s) - catalysis , combinatorial chemistry , chemistry , nanotechnology , materials science , organic chemistry
The first general methodology for the direct thiolation of electron‐rich heteroarenes was developed by employing Pd/Al 2 O 3 , a recoverable and commercially available heterogeneous catalyst, and CuCl 2 . This method represents an operationally simple approach for the synthesis of these valuable compounds. Preliminary mechanistic studies indicate a heterogeneous catalytic system, in which both metals play a complementary role in the formation of the thiolated products.