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Iron‐Catalyzed Asymmetric Hydrosilylation of 1,1‐Disubstituted Alkenes
Author(s) -
Chen Jianhui,
Cheng Biao,
Cao Minyi,
Lu Zhan
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411884
Subject(s) - hydrosilylation , markovnikov's rule , enantioselective synthesis , silanes , chemistry , oxazoline , catalysis , derivatization , organic chemistry , phenol , aryl , regioselectivity , silane , alkyl , high performance liquid chromatography
The highly regio‐ and enantioselective iron‐catalyzed anti‐Markovnikov hydrosilylation of 1,1‐disubstituted aryl alkenes was developed using iminopyridine oxazoline ligands to afford chiral organosilanes. Additional derivatization of these products lead to chiral organosilanols, cyclic silanes, phenol derivatives, and 3‐substituted 2,3‐dihydrobenzofurans.