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Manganese‐Catalyzed Synthesis of cis ‐β‐Amino Acid Esters through Organometallic CH Activation of Ketimines
Author(s) -
Liu Weiping,
Zell Daniel,
John Michael,
Ackermann Lutz
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411808
Subject(s) - regioselectivity , manganese , alkene , catalysis , chemistry , amino acid , functional group , group 2 organometallic chemistry , organometallic chemistry , surface modification , organic chemistry , combinatorial chemistry , molecule , biochemistry , polymer
Manganese‐catalyzed CH functionalization reactions of ketimines set the stage for the expedient synthesis of cis ‐β‐amino acid esters through site‐ and regioselective alkene annulations. The organometallic CH activation occurred efficiently with high functional group tolerance, delivering densely functionalized β‐amino acid derivatives with ample scope.