Premium
Silver‐Mediated Oxidative Aliphatic CH Trifluoromethylthiolation
Author(s) -
Guo Shuo,
Zhang Xiaofei,
Tang Pingping
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411807
Subject(s) - reagent , aqueous medium , chemistry , compatibility (geochemistry) , scope (computer science) , combinatorial chemistry , functional group , natural product , aqueous solution , oxidative phosphorylation , reaction conditions , organic chemistry , computer science , catalysis , chemical engineering , biochemistry , engineering , programming language , polymer
The first example of a practical and direct trifluoromethylthiolation reaction of unactivated aliphatic CH bonds employs a silver‐based reagent. The reaction is operationally simple, scalable, and proceeds under aqueous conditions in air. Furthermore, its broad scope and good functional‐group compatibility were demonstrated by applying this method to the selective trifluoromethylthiolation of natural products and natural‐product derivatives.