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Stereoselective Nickel‐Catalyzed [2+2] Cycloadditions of Ene‐Allenes
Author(s) -
Noucti Njamkou N.,
Alexanian Erik J.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411737
Subject(s) - cyclobutanes , allene , ene reaction , cycloaddition , stereoselectivity , chemistry , cyclobutane , catalysis , nickel , cyclobutene , combinatorial chemistry , stereochemistry , organic chemistry , ring (chemistry)
A stereoselective nickel‐catalyzed [2+2] cycloaddition of ene‐allenes is reported. This transformation encompasses a broad range of ene‐allene substrates, thus providing efficient access to fused cyclobutanes from easily accessed π‐components. A simple and inexpensive first‐row catalytic system comprised of [Ni(cod) 2 ] and dppf was used in this process, thus constituting an attractive approach to synthetically challenging cyclobutane frameworks under mild reaction conditions.