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Inside Cover: Interception of Cobalt‐Based Carbene Radicals with α‐Aminoalkyl Radicals: A Tandem Reaction for the Construction of β‐Ester‐γ‐amino Ketones (Angew. Chem. Int. Ed. 4/2015)
Author(s) -
Zhang Jie,
Jiang Jiewen,
Xu Dongmei,
Luo Qiang,
Wang Hongxiang,
Chen Jijun,
Li Huihuang,
Wang Yaxiong,
Wan Xiaobing
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411683
Subject(s) - carbene , radical , chemistry , olefin fiber , tandem , cobalt , catalysis , medicinal chemistry , ionic bonding , polymer chemistry , photochemistry , organic chemistry , materials science , ion , composite material
A tandem reaction for the construction of β‐ester‐γ‐amino ketones combines a carbene radical, an organoradical, and an ionic Kornblum–DeLaMare reaction into a single catalytic cycle. In their Communication on page 1231 ff., X. Wan and co‐workers show that once the cobalt‐based carbene radical intermediate has been generated, it can be intercepted with α‐aminoalkyl radicals instead of simply adding to an olefin.