Acylsulfonamide‐Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH | Zendy

Mizuhara Tsukasa | Zendy; Saha Krishnendu | Zendy; Moyano Daniel F. | Zendy; Kim Chang Soo | Zendy; Yan Bo | Zendy; Kim YoungKwan | Zendy; Rotello Vincent M. | Zendy

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Acylsulfonamide‐Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH

Author(s) -

Mizuhara Tsukasa,

Saha Krishnendu,

Moyano Daniel F.,

Kim Chang Soo,

Yan Bo,

Kim YoungKwan,

Rotello Vincent M.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201411615

Subject(s) - nanoparticle , chemistry , colloidal gold , ligand (biochemistry) , cytotoxicity , combinatorial chemistry , particle (ecology) , nanotechnology , in vitro , materials science , biochemistry , receptor , oceanography , geology

A nanoparticle design featuring pH‐responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH‐controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.

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