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Acylsulfonamide‐Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH
Author(s) -
Mizuhara Tsukasa,
Saha Krishnendu,
Moyano Daniel F.,
Kim Chang Soo,
Yan Bo,
Kim YoungKwan,
Rotello Vincent M.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411615
Subject(s) - nanoparticle , chemistry , colloidal gold , ligand (biochemistry) , cytotoxicity , combinatorial chemistry , particle (ecology) , nanotechnology , in vitro , materials science , biochemistry , receptor , oceanography , geology
A nanoparticle design featuring pH‐responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH‐controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.