Premium
Back Cover: Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6‐Aminohexanoic acid (Angew. Chem. Int. Ed. 51/2014)
Author(s) -
Sattler Johann H.,
Fuchs Michael,
Mutti Francesco G.,
Grischek Barbara,
Engel Philip,
Pfeffer Jan,
Woodley John M.,
Kroutil Wolfgang
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201411133
Subject(s) - cyclohexanol , cascade , monomer , biocatalysis , in situ , chemistry , combinatorial chemistry , cover (algebra) , polymer chemistry , materials science , stereochemistry , nanotechnology , organic chemistry , engineering , catalysis , reaction mechanism , chromatography , mechanical engineering , polymer
The one‐pot synthesis of a nylon‐6 monomer by a combination of two redox self‐sufficient biocatalytic modules (gray box and flask) is described by W. Kroutil et al. in their Communication on page 14153 ff. The cascade is shown as an electric circuit, whereby each enzyme is shown at a crossing and an in situ capping strategy prevents dead‐end inhibition by an intermediate. The proof of principle was shown by the synthesis of 6‐aminohexanoic acid starting from cyclohexanol only at the expense of NH 3 and O 2 . The graphic was designed by Verena Andrea Resch