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Cover Picture: Switching of Bacterial Adhesion to a Glycosylated Surface by Reversible Reorientation of the Carbohydrate Ligand (Angew. Chem. Int. Ed. 52/2014)
Author(s) -
Weber Theresa,
Chandrasekaran Vijayanand,
Stamer Insa,
Thygesen Mikkel B.,
Terfort Andreas,
Lindhorst Thisbe K.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410966
Subject(s) - azobenzene , glycocalyx , chemistry , sialyl lewis x , stereochemistry , ligand (biochemistry) , carbohydrate , isomerization , crystallography , adhesion , selectin , molecule , biochemistry , receptor , organic chemistry , catalysis
The Yin and Yang of carbohydrate recognition: Bacteria (shown in green) have lectin‐type appendages to adhere to glycosylated surfaces, such as the glycocalyx of host cells. In their Communication on page 14583 ff., A. Terfort, T. K. Lindhorst, and co‐workers use a photoswitchable azobenzene glycoside monolayer as a glycocalyx model. The orientation of the carbohydrate ligands is controlled by photochemical E / Z isomerization of the azobenzene hinge. Thus, for bacterial cells, binding or not binding is a question of the orientation of the carbohydrate ligands.