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Condensed‐Phase, Halogen‐Bonded CF 3 I and C 2 F 5 I Adducts for Perfluoroalkylation Reactions
Author(s) -
Sladojevich Filippo,
McNeill Eric,
Börgel Jonas,
Zheng ShaoLiang,
Ritter Tobias
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410954
Subject(s) - trifluoromethylation , reagent , halogen , adduct , chemistry , combinatorial chemistry , liquid phase , organic chemistry , trifluoromethyl , physics , thermodynamics , alkyl
A family of practical, liquid trifluoromethylation and pentafluoroethylation reagents is described. We show how halogen bonding can be used to obtain easily handled liquid reagents from gaseous CF 3 I and CF 3 CF 2 I. The synthetic utility of the new reagents is exemplified by a novel direct arene trifluoromethylation reaction as well as adaptations of other perfluoroalkylation reactions.