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Controlled Release of Encapsulated Bioactive Volatiles by Rupture of the Capsule Wall through the Light‐Induced Generation of a Gas
Author(s) -
Paret Nicolas,
Trachsel Alain,
Berthier Damien L.,
Herrmann Andreas
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410778
Subject(s) - capsule , irradiation , chemistry , light intensity , chemical engineering , materials science , nanotechnology , optics , physics , botany , nuclear physics , biology , engineering
The encapsulation of photolabile 2‐oxoacetates in core–shell microcapsules allows the light‐induced, controlled release of bioactive compounds. On irradiation with UVA light these compounds degrade to generate an overpressure of gas inside the capsules, which expands or breaks the capsule wall. Headspace measurements confirmed the light‐induced formation of CO and CO 2 and the successful release of the bioactive compound, while optical microscopy demonstrated the formation of gas bubbles, the cleavage of the capsule wall, and the leakage of the oil phase out of the capsule. The efficiency of the delivery system depends on the structure of the 2‐oxoacetate, the quantity used with respect to the thickness of the capsule wall, and the intensity of the irradiating UVA light.