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Regioselective Pd‐Catalyzed Methoxycarbonylation of Alkenes Using both Paraformaldehyde and Methanol as CO Surrogates
Author(s) -
Liu Qiang,
Yuan Kedong,
Arockiam PerciaBeatrice,
Franke Robert,
Doucet Henri,
Jackstell Ralf,
Beller Matthias
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410764
Subject(s) - paraformaldehyde , regioselectivity , carbonylation , catalysis , methanol , chemistry , hydroformylation , organic chemistry , palladium , combinatorial chemistry , carbon monoxide , rhodium
In recent years, considerable effort has focused on the development of novel carbonylative transformations using CO surrogates. Consequently, toxic CO gas can be replaced by more convenient inorganic or organic carbonyl compounds. Herein, the first regioselective methoxycarbonylation of alkenes with paraformaldehyde and methanol as CO substitutes is reported. This new procedure is applicable to a series of alkenes in the presence of a palladium catalyst under relatively mild conditions and is highly atom efficient.