Direct α‐Arylation of Ethers through the Combination of Photoredox‐Mediated CH Functionalization and the Minisci Reaction | Zendy

Jin Jian | Zendy; MacMillan David W. C. | Zendy

Premium

Direct α‐Arylation of Ethers through the Combination of Photoredox‐Mediated CH Functionalization and the Minisci Reaction

Author(s) -

Jin Jian,

MacMillan David W. C.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201410432

Subject(s) - surface modification , chemistry , radical , photoredox catalysis , pharmacophore , combinatorial chemistry , hydrogen atom , photochemistry , photocatalysis , organic chemistry , stereochemistry , catalysis , alkyl

The direct α‐arylation of cyclic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox‐mediated CH functionalization pathway. Transiently generated α‐oxyalkyl radicals, produced from a variety of widely available ethers through hydrogen atom transfer (HAT), were coupled with a range of electron‐deficient heteroarenes in a Minisci‐type mechanism. This mild, visible‐light‐driven protocol allows direct access to medicinal pharmacophores of broad utility using feedstock substrates and a commercial photocatalyst.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research