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Total Synthesis of (±)‐Hippolachnin A
Author(s) -
Ruider Stefan A.,
Sandmeier Tobias,
Carreira Erick M.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410419
Subject(s) - total synthesis , polyketide , yield (engineering) , core (optical fiber) , computer science , mathematics , stereochemistry , chemistry , telecommunications , physics , organic chemistry , biosynthesis , enzyme , thermodynamics
The first total synthesis of the marine polyketide (±)‐hippolachnin A has been achieved in nine linear steps and an overall yield of 9 %. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.