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Ferrocene‐Based Planar Chiral Imidazopyridinium Salts for Catalysis
Author(s) -
Check Christopher T.,
Jang Ki Po,
Schwamb C. Benjamin,
Wong Alexander S.,
Wang Michael H.,
Scheidt Karl A.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410118
Subject(s) - enantiopure drug , catalysis , enantioselective synthesis , combinatorial chemistry , carbene , planar chirality , steric effects , planar , chirality (physics) , chemistry , ligand (biochemistry) , ferrocene , nanotechnology , materials science , organic chemistry , computer science , physics , biochemistry , chiral symmetry breaking , computer graphics (images) , receptor , electrode , quantum mechanics , quark , nambu–jona lasinio model , electrochemistry
Abstract Planar chirality remains an underutilized control element in asymmetric catalysis. Factors that have limited its broader application in catalysis include poor catalyst performance and difficulties associated with the economical production of enantiopure planar chiral compounds. The construction of planar chiral azolium salts that incorporate a sterically demanding iron sandwich complex is now reported. Applications of this new N‐heterocyclic carbene as both an organocatalyst and a ligand for transition‐metal catalysis demonstrate its unprecedented versatility and potential broad utility in asymmetric catalysis.