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Inside Back Cover: Recognition of Nucleic Acid Junctions Using Triptycene‐Based Molecules (Angew. Chem. Int. Ed. 50/2014)
Author(s) -
Barros Stephanie A.,
Chenoweth David M.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201410021
Subject(s) - nucleic acid , triptycene , dna , rna , cover (algebra) , chemistry , scaffold , molecule , biophysics , nanotechnology , materials science , biology , biochemistry , engineering , biomedical engineering , gene , organic chemistry , mechanical engineering
Rationally designed nucleic acid junction binders based on a triptycene scaffold were found to significantly stabilize DNA and RNA three‐way junctions. In their Communication on page 13746 ff., D. M. Chenoweth and S. A. Barros report that the scaffold provides a new architecture for the development of junction binders with enhanced recognition properties. Initial cytotoxicity data in two human ovarian carcinoma cell lines are promising.