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Direct Dehydroxytrifluoromethylthiolation of Alcohols Using Silver(I) Trifluoromethanethiolate and Tetra‐ n ‐butylammonium Iodide
Author(s) -
Liu JianBo,
Xu XiuHua,
Chen ZengHao,
Qing FengLing
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409983
Subject(s) - tetra , iodide , alkyl , chemistry , medicinal chemistry , organic chemistry
Abstract An unprecedented reaction for the direct trifluoromethylthiolation and fluorination of alkyl alcohols using AgSCF 3 and nBu 4 NI has been developed. The trifluoromethylthiolated compounds and alkyl fluorides were selectively formed by changing the ratio of AgSCF 3 /nBu 4 NI. This protocol is tolerant of different functional groups and might be applicable to late‐stage trifluoromethylthiolation of alcohols.