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Heteroatom‐embedded Medium‐Sized Cycloalkynes: Concise Synthesis, Structural Analysis, and Reactions
Author(s) -
Ni Runyan,
Mitsuda Naoto,
Kashiwagi Takeru,
Igawa Kazunobu,
Tomooka Katsuhiko
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409910
Subject(s) - heteroatom , chemistry , organic chemistry , ring (chemistry)
A variety of medium‐sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.
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