Building Up Quarternary Stereocenters of Chromans by Asymmetric Redox Organocatalysis: A New Entry to Vitamin E | Zendy

Netscher Thomas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Building Up Quarternary Stereocenters of Chromans by Asymmetric Redox Organocatalysis: A New Entry to Vitamin E

Author(s) -

Netscher Thomas

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201409826

Subject(s) - stereocenter , enantioselective synthesis , organocatalysis , ammonium iodide , chemistry , catalysis , iodide , yield (engineering) , ammonium , organic chemistry , redox , combinatorial chemistry , materials science , metallurgy

High‐turnover catalysis offers a novel concept for the efficient chemo‐ and enantioselective preparation of chroman intermediates, which are useful for the synthesis of tocopherols (vitamin E components) and other biologically active compounds. A chiral ammonium iodide catalyst mediates the cycloetherification in combination with a cooxidant and an inorganic base in excellent yield and up to 93 % ee. OTs= para ‐toluenesulfonyl.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research