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Asymmetric Dearomatization of β‐Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid
Author(s) -
Wang ShouGuo,
Yin Qin,
Zhuo ChunXiang,
You ShuLi
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409756
Subject(s) - amination , phosphoric acid , catalysis , chemistry , organic chemistry , enantioselective synthesis , combinatorial chemistry
A highly efficient catalytic asymmetric dearomatization of naphthols by means of an electrophilic amination reaction catalyzed by chiral phosphoric acid is presented. This protocol provides a facile access to functionalized β‐naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity (up to 99 % yield, up to 96 % ee ).
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