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Highly Enantioselective Intermolecular Cross Rauhut–Currier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst
Author(s) -
Dong Xuelin,
Liang Ling,
Li Erqing,
Huang You
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409744
Subject(s) - catalysis , enantioselective synthesis , intermolecular force , lewis acids and bases , phosphine , base (topology) , chemistry , organic chemistry , molecule , mathematics , mathematical analysis
The highly enantioselective intermolecular cross Rauhut–Currier reaction of different active olefins catalyzed by a multifunctional chiral Lewis base was reported. The RC products were obtained in excellent yields (up to 98 %), high chemo‐ and enantioselectivity (up to 96 % ee ). The reaction could be performed on a gram scale using 1 mol % of the multifunctional phosphine catalyst.