Premium
Clotting Activity of Polyphosphate‐Functionalized Silica Nanoparticles
Author(s) -
Kudela Damien,
Smith Stephanie A.,
MayMasnou Anna,
Braun Gary B.,
Pallaoro Alessia,
Nguyen Chi K.,
Chuong Tracy T.,
Nownes Sara,
Allen Riley,
Parker Nicholas R.,
Rashidi Hooman H.,
Morrissey James H.,
Stucky Galen D.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409639
Subject(s) - clotting time , polyphosphate , hemostasis , thrombin , clotting factor , fibrin , platelet , single nucleotide polymorphism , snp , blood clotting , chemistry , medicine , biochemistry , immunology , gene , genotype , phosphate
We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood‐clotting system; short‐chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood‐clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP‐functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP‐SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP‐SNP even retains its clotting function at ambient temperature. The polyP‐SNP system has the potential to significantly improve trauma‐treatment protocols and outcomes in hospital and prehospital settings.