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Asymmetric Dual‐Reagent Catalysis: Mannich‐type Reactions Catalyzed by Ion Pair
Author(s) -
Wang HongYu,
Zhang Kai,
Zheng ChangWu,
Chai Zhuo,
Cao DongDong,
Zhang JiaXing,
Zhao Gang
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409342
Subject(s) - zwitterion , catalysis , bifunctional , reactivity (psychology) , chemistry , reagent , acrylate , combinatorial chemistry , phosphine , mannich reaction , substrate (aquarium) , organic chemistry , molecule , polymer , alternative medicine , geology , medicine , oceanography , monomer , pathology
The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion‐pairing mode. This new catalytic system has been successfully applied to Mannich‐type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.