Light‐Induced Protein Dimerization by One‐ and Two‐Photon Activation of Gibberellic Acid Derivatives in Living Cells | Zendy

Schelkle Korwin M. | Zendy; Griesbaum Tristan | Zendy; Ollech Dirk | Zendy; Becht Steffy | Zendy; Buckup Tiago | Zendy; Hamburger Manuel | Zendy; Wombacher Richard | Zendy

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Light‐Induced Protein Dimerization by One‐ and Two‐Photon Activation of Gibberellic Acid Derivatives in Living Cells

Author(s) -

Schelkle Korwin M.,

Griesbaum Tristan,

Ollech Dirk,

Becht Steffy,

Buckup Tiago,

Hamburger Manuel,

Wombacher Richard

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201409196

Subject(s) - gibberellic acid , chromosomal translocation , inducer , chemistry , photon , blue light , biophysics , photochemistry , biochemistry , biology , physics , optoelectronics , botany , optics , gene , germination

We developed a highly efficient system for light‐induced protein dimerization in live cells using photo‐caged derivatives of the phytohormone gibberellic acid (GA 3 ). We demonstrate the application of the photo‐activatable chemical inducer of dimerization (CID) for the control of protein translocation with high spatiotemporal precision using light as an external trigger. Furthermore, we present a new two‐photon (2P)‐sensitive caging group, whose exceptionally high two‐photon cross section allows the use of infrared light to efficiently unleash the active GA 3 for inducing protein dimerization in living cells.

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