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Inside Cover: Catalytic Asymmetric Functionalization of Aromatic CH Bonds by Electrophilic Trapping of Metal‐Carbene‐Induced Zwitterionic Intermediates (Angew. Chem. Int. Ed. 48/2014)
Author(s) -
Jia Shikun,
Xing Dong,
Zhang Dan,
Hu Wenhao
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201409113
Subject(s) - stereocenter , electrophile , surface modification , diazo , chemistry , carbene , catalysis , medicinal chemistry , enantioselective synthesis , organic chemistry
An asymmetric three‐component reaction of N , N ‐disubstituted anilines, diazo compounds, and imines is catalyzed by Rh II and a chiral phosphoric acid and affords α,α‐diaryl benzylic quaternary stereocenters. In their Communication on page 13098 ff., W. Hu, D. Xing et al. report this functionalization of aromatic CH bonds with diazo compounds, which they compare with a “magic tea pot” that allows the mixing of three different tea bags into a wonderful tea.