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Investigation of Single‐Drug‐Encapsulating Liposomes using the Nano‐Impact Method
Author(s) -
Cheng Wei,
Compton Richard G.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408934
Subject(s) - liposome , drug delivery , drug , nano , chemistry , nanotechnology , chromatography , materials science , pharmacology , medicine , composite material
Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano‐impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time.