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Identification and Accurate Size Characterization of Nanoparticles in Complex Media
Author(s) -
Liu Lihong,
He Bin,
Liu Qian,
Yun Zhaojun,
Yan Xueting,
Long Yanmin,
Jiang Guibin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408927
Subject(s) - electropherogram , electrokinetic phenomena , characterization (materials science) , mass spectrometry , nanoparticle , inductively coupled plasma mass spectrometry , analytical chemistry (journal) , materials science , biological system , chromatography , nanotechnology , chemistry , capillary electrophoresis , biology
Abstract We have developed a new method for the identification and accurate size characterization of nanoparticles (NPs) in complex media based on capillary electrokinetic (CE) separation coupled to inductively coupled plasma mass spectrometry (ICP‐MS). Through mass scanning and Gaussian fitting of electropherogram peaks, we can obtain multidimensional information on chemical compositions, size distributions, and ionic species of multiple NPs in a single run. The results are more accurate than those obtained by using conventional methods. This method provides a powerful tool for investigating polydisperse NP systems and rapid screening of NP‐containing products.