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Oxidative Photoredox‐Catalytic Activation of Aliphatic Nucleophiles for C(sp 3 )–C(sp 2 ) Cross‐Coupling Reactions
Author(s) -
Jahn Emanuela,
Jahn Ullrich
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408748
Subject(s) - nucleophile , chemistry , photoredox catalysis , catalysis , radical , photochemistry , iridium , reactivity (psychology) , alkyl , coupling reaction , oxidative phosphorylation , photocatalysis , organic chemistry , medicine , alternative medicine , pathology , biochemistry
In the light you will find the road (Led Zeppelin) : Visible‐light photoredox catalysis leads the way in overcoming the reactivity limitations of alkyl nucleophiles in cross‐coupling reactions. Iridium‐triggered oxidative photoredox activation of alkyltrifluoroborate or carboxylic acids affords alkyl radicals, which undergo nickel‐catalyzed cross‐coupling reactions.