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Ligand‐Promoted ortho ‐CH Amination with Pd Catalysts
Author(s) -
Zhu Dajian,
Yang Guoqiang,
He Jian,
Chu Ling,
Chen Gang,
Gong Wei,
Chen Ke,
Eastgate Martin D.,
Yu JinQuan
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408651
Subject(s) - amination , ligand (biochemistry) , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , biochemistry
2,4,6‐Trimethoxypyridine is identified as an efficient ligand for promoting a Pd‐catalyzed ortho‐CH amination of both benzamides and triflyl‐protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable Pd II ‐catalyzed C sp 2H activation reactions directed by weakly coordinating functional groups.