Premium
NeuO: a Fluorescent Chemical Probe for Live Neuron Labeling
Author(s) -
Er Jun Cheng,
Leong Cheryl,
Teoh Chai Lean,
Yuan Qiang,
Merchant Paolomi,
Dunn Matthew,
Sulzer David,
Sames Dalibor,
Bhinge Akshay,
Kim Dongyoon,
Kim SeongMin,
Yoon MyungHan,
Stanton Lawrence W.,
Je Shawn H.,
Yun SeongWook,
Chang YoungTae
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408614
Subject(s) - neuron , live cell imaging , fluorescence , neuroscience , cell , biology , biochemistry , physics , quantum mechanics
To address existing limitations in live neuron imaging, we have developed NeuO , a novel cell‐permeable fluorescent probe with an unprecedented ability to label and image live neurons selectively over other cells in the brain. NeuO enables robust live neuron imaging and isolation in vivo and in vitro across species; its versatility and ease of use sets the basis for its development in a myriad of neuronal targeting applications.