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Nitrimines as Reagents for Metal‐Free Formal C(sp 2 )–C(sp 2 ) Cross‐Coupling Reactions
Author(s) -
AngelesDunham Veronica V.,
Nickerson David M.,
Ray Devin M.,
Mattson Anita E.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408613
Subject(s) - reagent , yield (engineering) , stereoselectivity , coupling reaction , chemistry , combinatorial chemistry , coupling (piping) , metal , formal synthesis , computational chemistry , stereochemistry , organic chemistry , materials science , catalysis , metallurgy
Nitrimines are employed as powerful reagents for metal‐free formal C(sp 2 )–C(sp 2 ) cross‐coupling reactions. The new chemical process is tolerant of a wide array of nitrimine and heterocyclic coupling partners giving rise to the corresponding di‐ or trisubstituted alkenes, typically in high yield and with high stereoselectivity. This method is ideal for the metal‐free construction of heterocycle‐containing drug targets, such as phenprocoumon.