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PET Imaging of Bacterial Infections with Fluorine‐18‐Labeled Maltohexaose
Author(s) -
Ning Xinghai,
Seo Wonewoo,
Lee Seungjun,
Takemiya Kiyoko,
Rafi Mohammad,
Feng Xuli,
Weiss Daiana,
Wang Xiaojian,
Williams Larry,
Camp Ver M.,
Eugene Malveaux,
Taylor W. Robert,
Goodman Mark,
Murthy Niren
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408533
Subject(s) - in vivo , bacteria , positron emission tomography , microbiology and biotechnology , pet imaging , chemistry , drug resistance , nuclear medicine , biology , medicine , genetics
A positron emission tomography (PET) tracer composed of 18 F‐labeled maltohexaose (MH 18 F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ( 18 FDG). MH 18 F can detect early‐stage infections composed of as few as 10 5 E. coli colony‐forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH 18 F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.