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Specific Light‐Up Bioprobe with Aggregation‐Induced Emission and Activatable Photoactivity for the Targeted and Image‐Guided Photodynamic Ablation of Cancer Cells
Author(s) -
Yuan Youyong,
Zhang ChongJing,
Gao Meng,
Zhang Ruoyu,
Tang Ben Zhong,
Liu Bin
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408476
Subject(s) - phototoxicity , photodynamic therapy , photosensitizer , fluorescence , aggregation induced emission , chemistry , cancer cell , cancer , photochemistry , nanotechnology , materials science , in vitro , medicine , optics , biochemistry , organic chemistry , physics
Abstract Activatable photosensitizers (PSs) have been widely used for the simultaneous fluorescence imaging and photodynamic ablation of cancer cells. However, the ready aggregation of traditional PSs in aqueous media can lead to fluorescence quenching as well as reduced phototoxicity even in the activated form. We have developed a series of PSs that show aggregation‐enhanced emission and phototoxicity and thus the exact opposite behavior to that of previously reported PSs. We further developed a dual‐targeted enzyme‐activatable bioprobe based on the optimized photosensitizer and describe simultaneous light‐up fluorescence imaging and activated photodynamic therapy for specific cancer cells. The design of smart probes should thus open new opportunities for targeted and image‐guided photodynamic therapy.