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Stereodivergent Total Synthesis of Δ 9 ‐Tetrahydrocannabinols
Author(s) -
Schafroth Michael A.,
Zuccarello Giuseppe,
Krautwald Simon,
Sarlah David,
Carreira Erick M.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408380
Subject(s) - catalysis , total synthesis , dual (grammatical number) , stereochemistry , chemistry , combinatorial chemistry , stereoselectivity , organic chemistry , philosophy , linguistics
All four stereoisomers of Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.