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A General Palladium‐Catalyzed Method for Alkylation of Heteroarenes Using Secondary and Tertiary Alkyl Halides
Author(s) -
Wu Xiaojin,
See Jessica Wei Ting,
Xu Kai,
Hirao Hajime,
Roger Julien,
Hierso JeanCyrille,
Zhou Jianrong Steve
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408355
Subject(s) - halide , alkyl , alkylation , palladium , catalysis , chemistry , organic chemistry , medicinal chemistry
A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.