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Inside Cover: An Organotrifluoroborate for Broadly Applicable One‐Step 18 F‐Labeling (Angew. Chem. Int. Ed. 44/2014)
Author(s) -
Liu Zhibo,
Pourghiasian Maral,
Radtke Mark Alex,
Lau Joseph,
Pan Jinhe,
Dias Gemma M.,
Yapp Donald,
Lin KuoShyan,
Bénard Francois,
Perrin David M.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408269
Subject(s) - chemistry , fluoride , isotopic labeling , reactivity (psychology) , aqueous solution , cover (algebra) , conjugate , radiochemistry , ion exchange , int , combinatorial chemistry , ion , inorganic chemistry , organic chemistry , computer science , mechanical engineering , engineering , medicine , mathematical analysis , alternative medicine , mathematics , pathology , operating system
Time is the essence for 18 F labeling. The poor reactivity of aqueous fluoride ions has long been a challenge in 18 F labeling. In their Communication on page 11876 ff., D. M. Perrin et al. present trifluoroborate–peptide conjugates that are labeled by isotopic exchange in water within 15 minutes to provide 18 F tracers with high specific activity. Time‐consuming HPLC can be avoided. Several bioactive ligands enable PET imaging of in vivo targets.