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Palladium‐Catalyzed Direct CH Functionalization of Benzoquinone
Author(s) -
Walker Sarah E.,
JordanHore James A.,
Johnson David G.,
Macgregor Stuart A.,
Lee AiLan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408054
Subject(s) - surface modification , catalysis , chemistry , palladium , aryl , benzoquinone , acetone , cycloalkene , organic chemistry , combinatorial chemistry , polymer chemistry , alkyl
A direct Pd‐catalyzed CH functionalization of benzoquinone (BQ) can be controlled to give either mono‐ or disubstituted BQ, including the installation of two different groups in a one‐pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cycloalkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.