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Experimental and Computational Study of the Catalytic Asymmetric 4π‐Electrocyclization of N‐Heterocycles
Author(s) -
Raja Sadiya,
Nakajima Masaki,
Rueping Magnus
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201408020
Subject(s) - enantioselective synthesis , catalysis , chemistry , computational chemistry , combinatorial chemistry , organic chemistry
The first asymmetric metal‐catalyzed Nazarov cyclization of N‐heterocycles has been developed. The use of a chiral catalyst allows the enantioselective electrocyclization of N‐heterocycles under mild conditions and the corresponding products are obtained in good yields with excellent enantio‐ and diastereoselectivity. The reaction mechanism and the absolute configuration of the obtained products are explained by means of computational studies.