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Radical CH Functionalization of Heteroarenes under Electrochemical Control
Author(s) -
O'Brien Alexander G.,
Maruyama Akinobu,
Inokuma Yasuhide,
Fujita Makoto,
Baran Phil S.,
Blackmond Donna G.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407948
Subject(s) - surface modification , electrochemistry , chemistry , combinatorial chemistry , radical , peroxide , organic chemistry , electrode
Electrochemical reactions are shown to be effective for the CH functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the CH functionalization of a series of heterocycles of interest in medicinal chemistry.