Premium
Aspergillomarasmine A, an Inhibitor of Bacterial Metallo‐β‐Lactamases Conferring bla NDM and bla VIM Resistance
Author(s) -
von Nussbaum Franz,
Schiffer Guido
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407921
Subject(s) - meropenem , microbiology and biotechnology , enterobacteriaceae , natural product , biology , antibiotic resistance , antibiotics , gene , escherichia coli , genetics , biochemistry
Silencing the deadly “bla‐bla” of superbugs : The natural product aspergillomarasmine A (AMA) showed in vivo efficacy against Enterobacteriaceae, conferring broad β‐lactam resistance bla NDM‐1 (NDM‐1: New Delhi Metallo‐β‐lactamase 1). In rodents, the natural product restored efficacy of the gold standard meropenem by inhibition of the Zn‐containing active site in NDM‐1.