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“Post‐It” Type Connected DNA Created with a Reversible Covalent Cross‐Link
Author(s) -
TomásGamasa María,
Serdjukow Sascha,
Su Meng,
Müller Markus,
Carell Thomas
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407854
Subject(s) - link (geometry) , cross link , covalent bond , duplex (building) , dna , imine , chemistry , nanotechnology , materials science , computer science , biochemistry , computer network , organic chemistry , polymer , catalysis
We report the development of a new heterobase that is held together through reversible bonding. The so‐formed cross‐link adds strong stabilization to the DNA duplex. Despite this, the cross‐link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross‐link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.