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Chemoenzymatic Synthesis of Spinosyn A
Author(s) -
Kim Hak Joong,
Choi Seihyun,
Jeon Byungsun,
Kim Namho,
Pongdee Rongson,
Wu Qingquan,
Liu Hungwen
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407806
Subject(s) - polyketide , biosynthesis , chemistry , stereochemistry , polyketide synthase , enzyme , computational biology , combinatorial chemistry , biochemistry , biology
Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post‐PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post‐PKS modifications.