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Epitaxial Seeded Growth of Rare‐Earth Nanocrystals with Efficient 800 nm Near‐Infrared to 1525 nm Short‐Wavelength Infrared Downconversion Photoluminescence for In Vivo Bioimaging
Author(s) -
Wang Rui,
Li Xiaomin,
Zhou Lei,
Zhang Fan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407420
Subject(s) - photoluminescence , materials science , infrared , wavelength , optoelectronics , nanocrystal , fluorescence , photon upconversion , biocompatibility , luminescence , nanotechnology , optics , physics , metallurgy
Novel β‐NaGdF 4 /Na(Gd,Yb)F 4 :Er/NaYF 4 :Yb/NaNdF 4 :Yb core/shell 1/shell 2/shell 3 (C/S1/S2/S3) multi‐shell nanocrystals (NCs) have been synthesized and used as probes for in vivo imaging. They can be excited by near‐infrared (800 nm) radiation and emit short‐wavelength infrared (SWIR, 1525 nm) radiation. Excitation at 800 nm falls into the “biological transparency window”, which features low absorption by water and low heat generation and is considered to be the ideal excitation wavelength with the least impact on biological tissues. After coating with phospholipids, the water‐soluble NCs showed good biocompatibility and low toxicity. With efficient SWIR emission at 1525 nm, the probe is detectable in tissues at depths of up to 18 mm with a low detection threshold concentration (5 n M for the stomach of nude mice and 100 n M for the stomach of SD rats). These results highlight the potential of the probe for the in vivo monitoring of areas that are otherwise difficult to analyze.